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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHAT All Species: 1.52
Human Site: T65 Identified Species: 2.78
UniProt: P28329 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28329 NP_066266.3 748 82536 T65 S P H P R A A T R P P P L P A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001109211 626 70697
Dog Lupus familis XP_543902 686 76910 H48 D D D D D D Y H F E R I C S F
Cat Felis silvestris
Mouse Mus musculus Q03059 641 71834
Rat Rattus norvegicus P32738 640 71845
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509108 643 72737
Chicken Gallus gallus Q90YJ9 640 72605
Frog Xenopus laevis Q7ZXE1 659 74538 Q20 W R T I T S S Q P V L L R A Y
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 P56 H R L S N I T P S D T G W K D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299
Sea Urchin Strong. purpuratus XP_001185550 675 75787 G37 Q G K R G K R G P K G L P G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 T32 S A I V N Y S T Q K A Q F P V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 37.8 77.9 N.A. 74.7 74.7 N.A. 68.4 66 24 57 N.A. 37.5 N.A. 29.2 46.3
Protein Similarity: 100 N.A. 55.7 82.4 N.A. 79.1 79 N.A. 76.5 74 40.6 68.8 N.A. 56.1 N.A. 45.1 62.4
P-Site Identity: 100 N.A. 0 0 N.A. 0 0 N.A. 0 0 0 0 N.A. 0 N.A. 0 6.6
P-Site Similarity: 100 N.A. 0 0 N.A. 0 0 N.A. 0 0 13.3 0 N.A. 0 N.A. 0 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 8 0 0 0 8 0 0 8 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 8 8 8 8 8 0 0 0 8 0 0 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 8 % F
% Gly: 0 8 0 0 8 0 0 8 0 0 8 8 0 8 0 % G
% His: 8 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 8 0 0 8 0 0 0 16 0 0 0 8 0 % K
% Leu: 0 0 8 0 0 0 0 0 0 0 8 16 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 8 0 0 0 8 16 8 8 8 8 16 0 % P
% Gln: 8 0 0 0 0 0 0 8 8 0 0 8 0 0 0 % Q
% Arg: 0 16 0 8 8 0 8 0 8 0 8 0 8 0 0 % R
% Ser: 16 0 0 8 0 8 16 0 8 0 0 0 0 8 0 % S
% Thr: 0 0 8 0 8 0 8 16 0 0 8 0 0 0 0 % T
% Val: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 8 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _